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MICROBIAL BIODIVERSITY AND MULTIFUNCTIONALITY IN TERRESTRIAL ECOSYSTEMS: ROLE IN ECOLOGICAL PROCESSES AND RESPONSE TO DISTURBANCE

Soil performs essential functions in maintaining terrestrial ecosystems. The ability of soil to simultaneously perform these functions is defined as multifunctionality, which is strongly influenced by variations in the structure and activity of microbial communities, in turn modulated by land use and management practices. This PhD thesis aimed to clarify how different land uses and related management practices influence soil chemical, physical, and biological properties, the edaphic microbial...

Process Mining in Healthcare: Maintenance of Data and Models

This thesis investigates the complexities associated with the application of Process Mining (PM) and Machine Learning (ML) in the healthcare domain, with a specific focus on the long-term maintenance of data and models. Despite the transformative potential of these technologies in optimizing clinical pathways and operational efficiency, their adoption is frequently hindered by the high heterogeneity of medical data, the non-linear nature of clinical processes, and the performance degradation ...

METABOLOMIC AND LIPIDOMIC STUDIES IN DEGENERATIVE AND AGE-RELATED DISEASES

This translational research program is designed to identify and validate metabolomic and lipidomic molecular biomarkers for early diagnosis, prognostic stratification, and therapeutic monitoring in degenerative and age-related disorders. A central focus has been the investigation of oxysterols as pivotal intermediates within the cholesterol–oxidative stress–target-organ injury axis. The first two studies included 14 individuals with Alzheimer’s disease dementia (three of whom carried an NPC1 ...

Perception and assessment of geodiversity and cultural heritage to promote geotourism in the Irpinia area crossed by the disused Avellino- Rocchetta S. Antonio railway line

This research provides a comprehensive analysis of the geodiversity, geomorphodiversity, and cultural heritage along the decommissioned Avellino–Rocchetta S. Antonio railway line. The study area spans 1,589 km² along the inner margin of the Southern Apennines and includes regions in Campania (80.64%), Apulia (18%), and Basilicata (1.29%). This region forms a geo-cultural corridor of strategic importance. The inactive railway traverses an area with significant geological, geomorphological, and...

Omics approaches for identifying novel molecular targets of metabolic alterations “Modulation of hepatic metabolism and autophagy in MASLD”

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a high prevalent chronic liver disorder driven by ectopic lipid accumulation in hepatocytes and closely associated with obesity, type 2 diabetes, and metabolic syndrome. Current therapeutic approaches mainly target systemic metabolic risk factors and fail to directly address the hepatic molecular mechanisms underlying disease progression, particularly mitochondrial dysfunction, highlighting the need for more targeted therapeu...

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Tipologia
  • 8 Tesi23
Autore
  • BOLOGNA, Andrea1
  • CIULLO, Marianna1
  • COCCA, Jlenia1
  • CUSANO, Angelo1
  • CUTILLO, Enrico Alberto1
  • De Luca, Giuseppina1
  • ESPOSITO, Alessia1
  • ESPOSITO, Concetta1
  • FORGIONE, Annunziata1
  • GINOLFI, Michele1
Data di pubblicazione
  • 202623
Editore
  • Università degli Studi del Sannio...23
Settore disciplinare
  • Settore ING-IND/25 - Impianti Chi...1
  • Settore ING-INF/05 - Sistemi di E...1
  • Settore IUS/01 - Diritto Privato1
  • Settore SECS-S/06 - Metodi mat. d...1
Keyword
  • digital metasurfaces1
  • fault diagnostics1
  • machine learning1
  • multi- frequency synthesis1
  • reconfigurable intelligent surfaces1
  • space-time-coding.1
Lingua
  • eng21
  • ita3
Accesso al fulltext
  • open15
  • no fulltext8