The neurotoxicity of zinc, released from nerve terminals during global ischemia, may contribute to the delayed death of certain selectively vulnerable neuronal populations. A likely first event in zinc-induced neuronal death appears to be its permeation across the plasma membrane, largely through voltage-and agonist-gated calcium channels. Considering the possibility that cellular Zn2+ overload might be lethal for reasons similar to cellular calcium overload, we tested the hypothesis that Zn2+ neurotoxicity might be ... .
|Titolo:||Another facet of nitric oxide: reduction of toxic zinc influx through voltage-gated channels|
|Data di pubblicazione:||1991|
|Appare nelle tipologie:||2.1 Contributo in volume (Capitolo o Saggio)|