The effects of COVID-19 on the Italian economy were uneven across regions, with a slightly more severe impact in the North and a slower recovery in the South. The main determinants of the observed differences are investigated, focusing on regional structural factors such as sectoral composition, propensity to remote working, availability of human capital and technology, international openness, participation in global value chains. The analysis on short-term resilience in 2020 is complemented by a discussion on perspectives of growth for the 2021-2024 period, highlighting the elements of weakness of the Southern economy and the role possibly played by public policies
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