An efficient potassium carbonate-catalyzed synthesis of 3-substituted isoindolinones through tandem aldol/cyclization reactions of active methylene compounds with 2-cyanobenzaldehyde is described. The utility of the obtained isoindolinones has been demonstrated through an exploration of the chemical space by employing a series of interesting methodologies that led to diverse, highly functionalized compounds. Among them, a surprisingly straightforward potassiumcarbonate-catalyzed double tandem reaction led to tricyclic hemiaminal derivatives. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Synthesis and reactivity of the 3-substituted isoindolinone framework to assemble highly functionalized related structures
Filosa R.;
2012-01-01
Abstract
An efficient potassium carbonate-catalyzed synthesis of 3-substituted isoindolinones through tandem aldol/cyclization reactions of active methylene compounds with 2-cyanobenzaldehyde is described. The utility of the obtained isoindolinones has been demonstrated through an exploration of the chemical space by employing a series of interesting methodologies that led to diverse, highly functionalized compounds. Among them, a surprisingly straightforward potassiumcarbonate-catalyzed double tandem reaction led to tricyclic hemiaminal derivatives. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.File in questo prodotto:
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