We developed a discrete time, structured, mathe- matical model describing the epidemiology of X-linked recessive diseases, a class of genetic disorders.The model accounts for both de novo mutations and distinct reproduction rates of pro- creating couples depending on their health conditions. We found the exact solution to the model when de novo mutations are not significant and negligible reproduction rates are assigned to affected males. Our results have relevance for both system modeling and genetic epidemiology.
Non Linear Discrete Time Epidemiological Model for X-Linked Recessive Diseases
Del Vecchio C;Glielmo L.;
2014-01-01
Abstract
We developed a discrete time, structured, mathe- matical model describing the epidemiology of X-linked recessive diseases, a class of genetic disorders.The model accounts for both de novo mutations and distinct reproduction rates of pro- creating couples depending on their health conditions. We found the exact solution to the model when de novo mutations are not significant and negligible reproduction rates are assigned to affected males. Our results have relevance for both system modeling and genetic epidemiology.File in questo prodotto:
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